Best novel of the quarter century

[jd]

Ouch!

M&D is actually the only Pynchon I've not read.  I got through 100
pages and then classes got too busy and I had to put it down.
Planning on giving it a re-read this summer.

Do you have any specific points to make against it?  And, as an aside,
what do you think of Vineland, which many people seem to consider his
weakest? (Not necessarily the people on this list mind you, but every
time it's mentioned somewhere it seems to be derided as his lesser
work).